The Molecular Chaperones Interaction Networks in Protein Folding and Degradation Walid A Houry

ISBN: 9781493911295

Published: September 2nd 2014

Hardcover

485 pages


Description

The Molecular Chaperones Interaction Networks in Protein Folding and Degradation  by  Walid A Houry

The Molecular Chaperones Interaction Networks in Protein Folding and Degradation by Walid A Houry
September 2nd 2014 | Hardcover | PDF, EPUB, FB2, DjVu, talking book, mp3, RTF | 485 pages | ISBN: 9781493911295 | 8.36 Mb

Molecular chaperones are a fundamental group of proteins that have been identified only relatively recently. They are key components of a protein quality machinery in the cell which insures that the folding process of any newly-synthesized polypeptide chain results in the formation of a properly folded protein and that the folded protein is maintained in an active conformation throughout its functional lifetime. Molecular chaperones have been shown to play essential roles in cell viability under both normal and stress conditions.

Chaperones can also assist in the unfolding and degradation of misfolded proteins and in disaggregating preformed protein aggregates. Chaperones are also involved in other cellular functions including protein translocation across membranes, vesicle fusion events, and protein secretion.In recent years, tremendous advances have been made in our understanding of the biology, biochemistry, and biophysics of function of molecular chaperones.

In addition, recent technical developments in the fields of proteomics and genomics allowed us to obtain a global view of chaperone interaction networks. Finally, there is now a growing interest in the role of molecular chaperones in diseases.This bookwill providea comprehensive analysis of the structure and function of the diverse systems of molecular chaperones and their role in cell stress responses and in diseases from a global network perspective.



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